The aging of tissue is actually the aging of the cells that build the tissues. Cells, which once divided at a rapid rate, begin to divide at a slower rate, resulting in a reduction of cell functionality. This same process also occurs within the cells that comprise the walls of blood vessels, resulting in a decline in those vessels that provide nutrients and oxygen to the cells. The tissues become thin as a result, and begin a steady decline, losing their ability to perform regeneration. Everything goes into decline: from the level of collagen and elastin to the fat in the fat layer.
These aging tissues find it difficult to repair the damage, and along with the low quality of the extracellular matrix, results in the development of scars that can create dysfunction. Studies show that glucose plays a significant role in this process. As the cells age and become dysfunctional, glucose becomes less effective at entering the cells and starts to accumulate in the extracellular matrix. This accumulation increases the number of connections between the collagen and the elastin, resulting in loss of tissue elasticity.
The results certainly support the statement that CUSEFS has an immediate effect on wound healing in stalled chronic wounds. Continued use of CUSEFS helps to heal these wounds in a much timelier fashion.
In chronic wounds, cellular and sub-cellular activities are decreased. Treatment of chronic wounds benefits from ultrasound therapy by increasing local blood flow in the wound and preowned area, stimulating angiogenesis, increasing vascular permeability, cellular protein synthesis, and improving collagen substance and substance and configuration.
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