The aging of tissue is actually the aging of the cells that build the tissues. Cells, which once divided at a rapid rate, begin to divide at a slower rate, resulting in a reduction of cell functionality. This same process also occurs within the cells that comprise the walls of blood vessels, resulting in a decline in those vessels that provide nutrients and oxygen to the cells. The tissues become thin as a result, and begin a steady decline, losing their ability to perform regeneration. Everything goes into decline: from the level of collagen and elastin to the fat in the fat layer.

These aging tissues find it difficult to repair the damage, and along with the low quality of the extracellular matrix, results in the development of scars that can create dysfunction. Studies show that glucose plays a significant role in this process. As the cells age and become dysfunctional, glucose becomes less effective at entering the cells and starts to accumulate in the extracellular matrix. This accumulation increases the number of connections between the collagen and the elastin, resulting in loss of tissue elasticity.


  1. Flattening of cells and a resultant decline in epidermal thickness.
  2. Elastosis – a condition caused when the cells of the dermis produce less and less  collagen and elastin, which in turn causes loss of elasticity and the development of wrinkles.
  3. Decrease in sebum production, which in turn causes drier skin and reduction in elasticity.
  4. Lessening of fat mass, which results in a reduction in the subcutaneous layer thickness.
  5. Decline in muscle mass and its natural tension, resulting in a saggy look.
  6. A diminished number of nerve cells- neurons. As a result of reduced axons, fewer axons are innervating more motor units and the movement of the muscles is less refined.
  7. Reduction in the efficacy of the lymphatic system. As a result, the skin loses its glow and becomes puffy.


The decrease in blood flow and glucose's effects on skin elasticity amplifies the appearance of aging

Aging Skin Results From:
Decrease in Blood Flow
Wrinkles, loss of vibrant skin, and aging cells in blood vessel walls cause reduction in oxygen and nutrients to the cells. Tissue
becomes thinner, and there is a reduction in collagen and elastin.
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Loss in Elasticity
Glucose, unable to access cells,
concentrates in an extracellular matrix, increasing connections and the hardening of collagen and elastic reduces elasticity.
CellSound Aesthetics
Our ElectroSonic Resonance™
Treatments Combat the Aging Process
Ultrasound and electric fields increase blood flow. This results in an increased flow of nutrients, growth factors, and absorption of glucose.
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Increasing the
Absorption of Glucose:
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Repairs blood vessel walls
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Repairs collagen and elastin’s elasticity
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Creates new collagen
  1. Increases flow of blood, resulting in more nutrients, growth factors, and angiogenesis of new blood vessels. This process improves cells' metabolism and hence cell structure.
  2. Remodeling of existing collagen, elastin, and hyaluronic.
  3. Stimulates neo-callogenesis and neo-elastogenesis without any thermal injury or cavitation.
  4. Enriches sebum production due to a better flow of nutrients and oxygens.
  5. Improves fat layer volume due to better metabolism of fat cells.
  6. Enhances muscle volume and elasticity resulting in fewer wrinkles and a more youthful appearance.
  7. Increases skin movement due to better functioning of nerve cells.
  8. Heightens lymphatic flow resulting in healthier-looking skin, glowing and less puffiness. Improves overall lymph vessels health increasing the flush and removal of toxins that otherwise contribute to the cellular aging process of all tissues making up the face and neck.
  9. Cellsound face remodels the fibrous septae network. Fibrous septae connect the dermis to the underlying muscle fascia. This critical structure otherwise becomes stretched and attenuated from aging.
  10. With the synced use of the electric field generated by our ElectroSonic Resonance™ treatment, the CELLSOUND FACE non-focused ultrasound penetrates to a depth of 2.5 cm and thus treats all cells and associated tissues of the face and neck.
  11. Cellsound’s maximum penetration improves blood flow in deep tissue and collagen/elastin regenerative functionality.


The results certainly support the statement that CUSEFS has an immediate effect on wound healing in stalled chronic wounds. Continued use of CUSEFS helps to heal these wounds in a much timelier fashion.

  • ​Abrizia Toscanella,1 Jonathan Rosenblum, 2 Sean Rosenblum, 3
  • ​1Casa Di Cura Villa Tiberia, Rome, Italy; 2 Shaare Zedek Medical Center, Jerusalem, Israel; 3 Private Practice, Lodi, NJ, USA

In chronic wounds, cellular and sub-cellular activities are decreased. Treatment of chronic wounds benefits from ultrasound therapy by increasing local blood flow in the wound and preowned area, stimulating angiogenesis, increasing vascular permeability, cellular protein synthesis, and improving collagen substance and substance and configuration.


  • Early Effects of Combined Ultrasound and Electric Field Stimulation on Chronic, Recalcitrant Skin Ulcerations Jonathan Rosenblum 1*, Fabrizia Toscanella 2 , Ram Avrahami 3, Sean Rosenblum 4 and Diane Eng 5 1 Israel Amputation Center, Jerusalem, Israel 2 Diabetic
  • Foot Service, Villa Tiberia, Rome, Italy 3 Wound Care Service, Clalit Medical, Tel Aviv, Israel 4 Private Practice, Lodi, NJ, USA 5 Wound Care Service, TTSH, Singapore *Corresponding author: Jonathan Rosenblum, Medical Director, Israel Amputation Center, Jerusalem, Israel, Tel: 7207443222; E-mail: Received date: June 25, 2016; Accepted date: July 18, 2017; Published date: July 24, 2017 Copyright: ©2017 Rosenblum J, et al. This is an open-access article distributed under the terms of the Creative Commons
  • Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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